Louden Analytics statistics
Christopher Louden implements your data science and statistics projects.
On Rising Up Against Statistical Significance
Valentin Amrhein, Sander Greenland, and Blake McShane write in Nature that because people often have a poor grasp of the concept of a p-value or the meaning of statistical significance, that we should stop categorizing results as statistically significant or non-statistically significant and replacing statistical significance with confidence intervals. While I agree with their goal, I think that we should be more careful in our solution to the problem.
The Ethics of Study Design
Because including humans (and animals) in a clinical trial exposes them to risk, we must design all aspects of the clinical trial ethically. Others can better discuss how consent, protection of protected populations and similar topics should be handled. I want to focus instead on how the statistical design of a clinical trial impacts the ethics of the trial.
The Bayesian Approach to Sample Size Calculations
Sample Size determination is generally done using a frequentist approach. However, Bayesian approaches can also be used allowing a researcher to take into account prior information as well as handle uncertainty about parameters used in the frequentist approach.
Using Pilot Studies in Clinical Research
A pilot study is a smaller version of a planned study. The purpose of the pilot study is to test the design of the larger study to improve its likelihood of success. Unfortunately, there are several misconceptions about what a pilot study is for.